artículo académico

• A rapid liquid chromatographic method with evaporative light scattering detection for postmortem glucose measurement in vitreous humor.  JOURNAL OF THE CHILEAN CHEMICAL SOCIETY.  70(2):6326-6329. 2025
• Development and optimization of teriflunomide-loaded chondroitin sulphate-coated nanostructured lipid carriers (NLCs) through box behnken design.  JOURNAL OF THE CHILEAN CHEMICAL SOCIETY.  68(2):5832-5838. 2023
• Evaluation of the Effects of Gamma Radiation Sterilization on Rhein-Loaded Biodegradable Microparticles for the Treatment of Osteoarthritis.  JOURNAL OF PHARMACEUTICAL SCIENCES.  112(3):837-843. 2023
• Determination of the Chemical Stability of Dapagliflozin by LC/DAD and MS/MS Methods.  JOURNAL OF CHROMATOGRAPHIC SCIENCE.  60(8):741-749. 2022
• Degradation studies of quetiapine fumarate by liquid chromatography-diode array detection and tandem mass spectrometry methods.  BIOMEDICAL CHROMATOGRAPHY.  33(11):1-8. 2019
• Determination of vortioxetine and its degradation product in bulk and tablets, by LC-DAD and MS/MS methods.  BIOMEDICAL CHROMATOGRAPHY.  32(11):1-6. 2018
• Optimization of rhein-loaded polymeric nanoparticles using a factorial design and evaluation of the cytotoxic and anti-inflammatory effects.  DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY.  44(8):1285-1294. 2018
• Stability-Indicating Liquid Chromatographic Methods with Photodiode Array Detection and Light Scattering Detection for Simultaneous Determination of Candesartan and Hydrochlorothiazide.  JOURNAL OF CHROMATOGRAPHIC SCIENCE.  56(2):99-107. 2018
• Development, characterization and in vitro evaluation of biodegradable rhein-loaded microparticles for treatment of osteoarthritis.  EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES.  96:390-397. 2017
• Comparison of Stability-Indicating LC Methods Using Light Scattering and Photodiode Array Detection with Monolithic Column for Determination of Quinapril and Hydrochlorothiazide.  JOURNAL OF CHROMATOGRAPHIC SCIENCE.  54(8):1346-1351. 2016
• Capreomycin oleate microparticles for intramuscular administration: preparation, in vitro release and preliminary in vivo evaluation.  JOURNAL OF CONTROLLED RELEASE.  209:229-237. 2015
• NP/HILIC-ELSD separation of phospholipid classes, application to preliminary analysis of plasma low density lipoproteins.  JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES.  38:243-250. 2015
• A validated stability-indicating LC method for simultaneous determination of quinapril and hydrochlorothiazide in pharmaceutical samples.  CENTRAL EUROPEAN JOURNAL OF CHEMISTRY.  12(4):470-475. 2014
• Desarrollo de nanopartículas biodegradables de capsaicina y evaluación de cesión del principio activo desde formulaciones semisolidas.  REVISTA DE FARMACOLOGÍA DE CHILE.  7(2):41-49. 2014
• Development of biodegradable methylprednisolone microparticles for treatment of articular pathology using a spray-drying technique.  INTERNATIONAL JOURNAL OF NANOMEDICINE.  8:2065-2076. 2013
• Successful factorial design for the optimization of methylprednisolone encapsulation in biodegradable nanoparticles.  DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY.  39(2):310-320. 2013
• Identification of phospholipid species affected by miltefosine action in Leishmania donovani cultures using LC-ELSD, LC-ESI/MS and multivariate data analysis.  ANALYTICAL AND BIOANALYTICAL CHEMISTRY.  402:1169-1182. 2012
• Chemical Stability of Enalapril maleate Drug Substance and Tablets by a Stability-Indicating Liquid Chromatographic Method.  QUIMICA NOVA.  34(3):450-454. 2011
• Stress degradation studies of ramipril by a validated stability-indicating liquid chromatographic method.  JOURNAL OF THE CHILEAN CHEMICAL SOCIETY.  55(4):450-453. 2010
• Comparison Between Charged Aerosol Detection and Light Scattering Detection for the Analysis of Leishmania Membrane Phospholipids.  JOURNAL OF CHROMATOGRAPHY A.  1209(1-2):88-94. 2008
• Evaluating Average Bioequivalence Using Methods for High Variability Drugs: A Case Study.  JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS.  46. 2008
• Determination of Ceftriaxone in Cerebrosspinal Fluid by Ion-Pair Liquid Chromatography.  JOURNAL OF AOAC INTERNATIONAL.  88(2):436-439. 2005
• Method Validation for the Determination of Furosemide in Plasma by Liquid-Liquid Extrraction and High-Performance Liquid Chromatography with Fluorescence Detection.  JOURNAL OF THE CHILEAN CHEMICAL SOCIETY.  50(2):479-482. 2005
• Liquid Chromatographic Assay for Fast Determination of Simvastatin in Drug Substance.  JOURNAL OF THE CHILEAN CHEMICAL SOCIETY.  48(4):289-290. 2004
• Stability of Ceftriaxone in Water and Cerebrospinal Fluid Determined by High-Performance Liquid Chromatography.  JOURNAL OF SEPARATION SCIENCE.  26:939-942. 2003
• Instrumental Planar Chromatographic Determination of Benzodiazepines: Comparison with Liquid Chromatography and Gas Chromatography.  JOURNAL OF AOAC INTERNATIONAL.  84(4):1287-1295. 2001