artículo académico

• Unraveling the neuroprotective mechanisms of elephant black garlic extract against beta amyloid peptide-induced neurotoxicity.  FRONTIERS IN NUTRITION.  12. 2026
• Allosteric modulation and direct activation of glycine receptors by a tricyclic sulfonamide..  SCIENTIFIC REPORTS.  15(1). 2025
• In Silico Characterization of Gelsemium Compounds as Glycine Receptor Ligands.  COMPOUNDS.  5(4). 2025
• The Alkaloid Gelsemine Reduces Aß Peptide Toxicity by Targeting Transglutaminase Type 2 Enzyme.  PLANTS-BASEL.  14(10). 2025
• Molecular Pharmacology of Gelsemium Alkaloids on Inhibitory Receptors.  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES.  25(6). 2024
• Modulation of GABAA receptors and of GABAergic synapses by the natural alkaloid gelsemine.  FRONTIERS IN MOLECULAR NEUROSCIENCE.  15. 2023
• TG2 promotes amyloid beta aggregates: Impact on ER-mitochondria crosstalk, calcium homeostasis and synaptic function in Alzheimer's disease.  BIOMEDICINE & PHARMACOTHERAPY.  162. 2023
• Understanding the Role of ATP Release through Connexins Hemichannels during Neurulation.  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES.  24(3). 2023
• Antiseizure medication in early nervous system development. Ion channels and synaptic proteins as principal targets.  FRONTIERS IN PHARMACOLOGY.  13. 2022
• Contribution of GlyR alpha 3 Subunits to the Sensitivity and Effect of Ethanol in the Nucleus Accumbens.  FRONTIERS IN MOLECULAR NEUROSCIENCE.  14. 2021
• Modulatory Actions of the Glycine Receptor ß Subunit on the Positive Allosteric Modulation of Ethanol in a2 Containing Receptors.  FRONTIERS IN MOLECULAR NEUROSCIENCE.  14(18). 2021
• Altered Glutaminase 1 Activity During Neurulation and Its Potential Implications in Neural Tube Defects.  FRONTIERS IN PHARMACOLOGY.  11. 2020
• Changes in PGC-1 alpha/SIRT1 Signaling Impact on Mitochondrial Homeostasis in Amyloid-Beta Peptide Toxicity Model.  FRONTIERS IN PHARMACOLOGY.  11. 2020
• Inhibition of the Glycine Receptor alpha 3 Function by Colchicine.  FRONTIERS IN PHARMACOLOGY.  11. 2020
• Modulation of glycine receptor single-channel conductance by intracellular phosphorylation.  SCIENTIFIC REPORTS.  10(1). 2020
• Stereospecific Inhibition of Ethanol Potentiation on Glycine Receptor by M554 Stereoisomers.  JOURNAL OF CHEMICAL INFORMATION AND MODELING.  60(12):6634-6641. 2020
• 17 Oxo Sparteine and Lupanine, Obtained from Cytisus scoparius, Exert a Neuroprotection against Soluble Oligomers of Amyloid-beta Toxicity by Nicotinic Acetylcholine Receptors.  JOURNAL OF ALZHEIMERS DISEASE.  67(1):343-356. 2019
• Inhibitory Actions of Tropeines on the alpha 3 Glycine Receptor Function.  FRONTIERS IN PHARMACOLOGY.  10. 2019
• Large Intracellular Domain-Dependent Effects of Positive Allosteric Modulators on Glycine Receptors.  ACS CHEMICAL NEUROSCIENCE.  10(5):2551-2559. 2019
• Cytotoxicity and in vivo plasma kinetic behavior of surface-functionalized PAMAM dendrimers.  NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE.  14(7):2227-2234. 2018
• P2X receptor overexpression induced by soluble oligomers of amyloid beta peptide potentiates synaptic failure and neuronal dyshomeostasis in cellular models of alzheimer´s disease.  NEUROPHARMACOLOGY.  128:366-378. 2018
• Presence of Inhibitory Glycinergic Transmission in Medium Spiny Neurons in the Nucleus Accumbens.  FRONTIERS IN MOLECULAR NEUROSCIENCE.  11:1-15. 2018
• Prevention of Synaptic Alterations and Neurotoxic Effects of PAMAM Dendrimers by Surface Functionalization.  NANOMATERIALS.  8(1):1-12. 2018
• Functional modulation of glycine receptors by the alkaloid gelsemine.  BRITISH JOURNAL OF PHARMACOLOGY.  173(14):2263-2277. 2016
• Phosphorylation state-dependent modulation of spinal glycine receptors alleviates inflammatory pain.  JOURNAL OF CLINICAL INVESTIGATION.  126(7):2547-2560. 2016
• Reversal of Ethanol-Induced Intoxication by a Novel Modulator of Gß¿ Potentiation of Glycine Receptor.  JOURNAL OF BIOLOGICAL CHEMISTRY.  291:18791-18798. 2016
• Several posttranslational modifications act in concert to regulate gephyrin scaffolding and GABAergic transmission.  NATURE COMMUNICATIONS.  7:1-16. 2016
• Structure and Pharmacologic Modulation of Inhibitory Glycine Receptors.  MOLECULAR PHARMACOLOGY.  90(3):318-325. 2016
• Control of Ethanol sensitivity of the Glycene receptor a3 Subunit by Transmembrane 2, the Intracellular Splice Cassette and C-Terminal Domain.  JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS.  353:80-90. 2015
• A single phenylalanine residue in the main intracellular loop of a1 y-aminobutyric acid type A and glycine receptors influences their sensitivity to propofol..  ANESTHESIOLOGY.  115(3):464-473. 2011
• Activated G protein as subunits increase the ethanol sensitivity of human glycine receptors..  JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS.  339(2):386-393. 2011
• Molecular Requirements for Ethanol Differential Allosteric Modulation of Glycine Receptors Based on Slective Gbetagamma Modulation.  JOURNAL OF BIOLOGICAL CHEMISTRY.  285(39):30203-30213. 2010