artículo académico

• Knocking down the neuronal lactate transporter MCT2 in the arcuate nucleus of female rats increases food intake and body weight.  SCIENTIFIC REPORTS.  15(1). 2025
• Poly (I:C)-induced inflammation requires the activation of toll-like receptor 3/Ca2+/CaMKII/pannexin 1-dependent signaling.  THERANOSTICS.  15(6):2470-2486. 2025
• Enhancing late postmortem interval prediction: a pilot study integrating proteomics and machine learning to distinguish human bone remains over 15 years.  BIOLOGICAL RESEARCH.  57(1). 2024
• Regulatory T cells administration reduces anxiety-like behavior in mice submitted to chronic restraint stress.  FRONTIERS IN CELLULAR NEUROSCIENCE.  18. 2024
• Targeting the immunoproteasome in hypothalamic neurons as a novel therapeutic strategy for high-fat diet-induced obesity and metabolic dysregulation.  JOURNAL OF NEUROINFLAMMATION.  21(1). 2024
• Lactate: an alternative pathway for the immunosuppressive properties of mesenchymal stem/stromal cells.  STEM CELL RESEARCH & THERAPY.  14(1). 2023
• A Short-Term Sucrose Diet Impacts Cell Proliferation of Neural Precursors in the Adult Hypothalamus.  NUTRIENTS.  14(13). 2022
• Association of the dopamine D2 receptor rs1800497 polymorphism with food addiction, food reinforcement, and eating behavior in Chilean adults.  EATING AND WEIGHT DISORDERS-STUDIES ON ANOREXIA BULIMIA AND OBESITY.  27(1):215-224. 2022
• GKRP-dependent modulation of feeding behavior by tanycyte-released monocarboxylates.  THERANOSTICS.  12(4):1518-1536. 2022
• GLUT2 expression by glial fibrillary acidic protein-positive tanycytes is required for promoting feeding-response to fasting.  SCIENTIFIC REPORTS.  12(1). 2022
• New Insights into the Determinants of Specificity in Human Type I Arginase: Generation of a Mutant That Is Only Active with Agmatine as Substrate.  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES.  23(12). 2022
• Lactate activates hypothalamic POMC neurons by intercellular signaling.  SCIENTIFIC REPORTS.  11(1). 2021
• The ATP synthase inhibition induces an AMPK-dependent glycolytic switch of mesenchymal stem cells that enhances their immunotherapeutic potential.  THERANOSTICS.  11(1):445-460. 2021
• HIF1 alpha-dependent metabolic reprogramming governs mesenchymal stem/stromal cell immunoregulatory functions.  FASEB JOURNAL.  34(6):8250-8264. 2020
• Inhibition of hypothalamic MCT4 and MCT1-MCT4 Expressions affects food intake and alters orexigenic anorexigenic neuropeptide expressions.  MOLECULAR NEUROBIOLOGY.  57(2):896-909. 2020
• Insights into the Mn2+ Binding Site in the Agmatinase-Like Protein (ALP): A Critical Enzyme for the Regulation of Agmatine Levels in Mammals.  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES.  21(11). 2020
• Insights on the participation of Glu256 and Asp204 in the oligomeric structure and cooperative effects of human arginase type I.  JOURNAL OF STRUCTURAL BIOLOGY.  211(2). 2020
• PPAR beta/delta-dependent MSC metabolism determines their immunoregulatory properties.  SCIENTIFIC REPORTS.  10(1). 2020
• The FGF2-induced tanycyte proliferation involves a connexin 43 hemichannel/purinergic-dependent pathway.  JOURNAL OF NEUROCHEMISTRY.  156(2):182-199. 2020
• Tympanic Membrane Rupture During Stereotaxic Surgery Disturbs the Normal Feeding Behavior in Rats.  FRONTIERS IN BEHAVIORAL NEUROSCIENCE.  14. 2020
• Glucose Increase DAGL alpha Levels in Tanycytes and Its Inhibition Alters Orexigenic and Anorexigenic Neuropeptides Expression in Response to Glucose.  FRONTIERS IN ENDOCRINOLOGY.  10. 2019
• When a Little Bit More Makes the Difference: Expression Levels of GKRP Determines the Subcellular Localization of GK in Tanycytes.  FRONTIERS IN NEUROSCIENCE.  13:1-14. 2019
• Connexin-43 Gap Junctions Are Responsible for the Hypothalamic Tanycyte-Coupled Network.  FRONTIERS IN CELLULAR NEUROSCIENCE.  12:1-15. 2018
• Glial hypothalamic inhibition of GLUT2 expression alters satiety, impacting eating behavior.  GLIA.  66(3):592-605. 2018
• SALL2 represses cyclins D1 and E1 expression and restrains G1/S cell cycle transition and cancer-related phenotypes.  MOLECULAR ONCOLOGY.  12(7):1026-1046. 2018
• Adenovirus-mediated suppression of hypothalamic glucokinase affects feeding behavior.  SCIENTIFIC REPORTS.  7:1-13. 2017
• Mammalian agmatinases constitute unusual members in the family of Mn2+-dependent ureahydrolases.  JOURNAL OF INORGANIC BIOCHEMISTRY.  166:122-125. 2017
• Cloning of two LIMCH1 isoforms: characterization of their distribution in rat brain and their agmatinase activity.  HISTOCHEMISTRY AND CELL BIOLOGY.  145:305-313. 2016
• Inhibition of hypothalamic MCT1 expression increases food intake and alters orexigenic and anorexigenic neuropeptide expression.  SCIENTIFIC REPORTS.  6:1-13. 2016
• Monocarboxylate transporters (MCTs) and their role in hypothalamic glucose detection.  MOJ CELL SCIENCE & REPORT.  3(4):66-70. 2016
• Insight on the interaction of an agmatinase-like protein with Mn (2+) activator ions.  JOURNAL OF INORGANIC BIOCHEMISTRY.  145:65-69. 2015
• The role of Tanycytes in Hypothalamic Glucosensing.  JOURNAL OF CELLULAR AND MOLECULAR MEDICINE.  19(7):1471-1482. 2015
• Dynamic Localization of Glucokinase adn regulatory Protein Hypothalamic Tanycytes.  PLOS ONE.  9(4):1-18. 2014
• SVCT2 transporter expression is post-natally induced in cortical neurons and its function is regulated by its short isoform.  JOURNAL OF NEUROCHEMISTRY.  130(5):693-706. 2014
• Clinical and experimental approaches to knee cartilage lesion repair and mesenchymal stem cell chondrocyte differentiation.  BIOLOGICAL RESEARCH.  46(4):441-451. 2013
• Dynamic expression of the sodium-vitamin C co-transporters, SVCT1 and SVCT2, during perinatal kidney development.  HISTOCHEMISTRY AND CELL BIOLOGY.  139:233-247. 2013
• Human choroid plexus papilloma cells efficiently transport glucose and vitamin C.  JOURNAL OF NEUROCHEMISTRY.  127(3):403-414. 2013
• MCT2 Expression and Lactate Influx in Anorexigenic and Orexigenic Neurons of the Arcuate Nucleus.  PLOS ONE.  8(4):1-15. 2013
• Superoxide-dependent uptake of vitamin C in human glioma cells.  JOURNAL OF NEUROCHEMISTRY.  13:1-12. 2013
• Control cerebral de la homeostasis de la glucosa. Interacción Glia-Neurona.  JOURNAL OF BIOMEDICAL SCIENCE.  3:29-39. 2012
• Glucose Increases Intracellular Free Ca2+ in Tanycytes via ATP Released Through Connexin 43 Hemichannels.  GLIA.  60:53-68. 2012
• Glucose Transporter 1 and Monocarboxylate Transporters 1,2 and 4 Localization within the Glial Cells of Shark Blood-Brain-Barriers.  PLOS ONE.  7(2):e32409. 2012
• Typical and atypical stem cells in the brain, vitamin C effect and neuropathology.  BIOLOGICAL RESEARCH.  45:243-256. 2012
• Expression and distribution of facilitative glucosa (Gluts) and monocarboxylate/H+ (MCTs) transporters in rat olfatoty epithelia.  CHEMICAL SENSES.  36(9):771-780. 2011
• Insulin regulates GLUT-1 medianted glucose transport in MG-63 human osteosarcoma .  JOURNAL OF CELLULAR PHYSIOLOGY.  226:1425-1432. 2011
• MCT Expression and Lactate Influx/Efflux in Tanycytes Involved in Glia-Neuron Metabolic Interaction.  PLOS ONE.  6(1):16411-16428. 2011
• Expression and Localization of an Agmatinase-Like Protein in the Rat Brain.  HISTOCHEMISTRY AND CELL BIOLOGY.  134:137-144. 2010
• Glial Glucokinase Expression in Adult and Post-Natal Development of the Hypothalamic Region.  ASN NEURO.  2(3):135-145. 2010
• Glucose Transporters in Sex Steroid Hormone Related Cancer.  CURRENT VASCULAR PHARMACOLOGY.  7:534-548. 2009
• The Na+-Dependent L-Ascorbic Acid Transporter SVCT2 Expressed in Brainstem Cells, Neurons, and Neuroblastoma Cells is Inhibited by Flavonoids.  JOURNAL OF NEUROCHEMISTRY.  108(3):563-577. 2009
• Differential Distribution of the Sodium-Vitamin C Cotransporter-1 Along the Proximal Tubule of the Mouse and Human Kidney.  KIDNEY INTERNATIONAL.  74(10):1278-1286. 2008
• Nutritional Channels in Breast Cancer.  JOURNAL OF CELLULAR AND MOLECULAR MEDICINE.  12(6):1-12. 2008
• Regulation of GLUT3 and Glucose Uptake by the cAMP Signalling Pathway in the Breast Cancer Cell Line ZR-75.  JOURNAL OF CELLULAR PHYSIOLOGY.  214(1):110-116. 2008
• Intracellular Ascorbic Acid Inhibits Transport of Glucose by Neurons, but not by Astrocytes.  JOURNAL OF NEUROCHEMISTRY.  102:773-782. 2007
• Differential Subcellular Distribution of Glucose Transporters CLUT1-6 and GLUT9 in Human Cancer: Ultrastructural Localization of GLUT1 and LUT5 in Breast Tumor Tissues.  JOURNAL OF CELLULAR PHYSIOLOGY.  207:614-627. 2006
• Cytogenetic Damage in Female Chilean Agricultural Workers Exposed to Mixtures of Pesticides.  ENVIRONMENTAL AND MOLECULAR MUTAGENESIS.  45:1-7. 2005
• Ependymal Cell Di Erentiation and GLUT1 Expression is a Synchronous Process in the Ventricular Wall.  NEUROCHEMICAL RESEARCH.  30(10):1227-1236. 2005
• Novel Expression of Liver FBPase in Langerhans Islets of Human and Rat Pancreas.  JOURNAL OF CELLULAR PHYSIOLOGY.  9999:1-6. 2005
• Sodium Vitamin C Cotransporter SVCT2 Is Expressed in Hypothalamic Glial Cells.  GLIA.  50:32-47. 2005
• Vitamin C Uptake and Recycling Among Normal and tumor Cells From the Central Nervous System.  JOURNAL OF NEUROSCIENCE RESEARCH.  79:146-156. 2005
• Regulation by Insulin and Insulin-like Growth Factor of 2-Deoxyglucose Uptake in Primary Ependymal Cell Cultures.  NEUROCHEMICAL RESEARCH.  29(1):127-134. 2004
• Estrogen and Progesterone Up-Regulate Glucose Transporter Expression in ZR-75-1 Human Breast Cancer Cells.  ENDOCRINOLOGY.  144(1:4527-4535. 2003
• Human Brain Synembryn Interacts with Gsa and Gqa and Is translocated to the Plasma Membrane in Response to Isoproterenol and Carbachol.  JOURNAL OF CELLULAR PHYSIOLOGY.  195:151-157. 2003
• Hypothalamic Ependymal-glial Cells Express the Glucose Transporter GLUT2, a Protein Involved in Glucose Sensing.  JOURNAL OF NEUROCHEMISTRY.  86:709-724. 2003