Puesto de trabajo HR
- Profesor Asistente
Cerrar
Ramirez Sanchez, David Mauricio
Posiciones
- Profesor Asistente, Departamento de Farmacología , Facultad de Ciencias Biológicas
Visión General
Publicaciones
publicaciones seleccionadas
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artículo académico
- Bromhexine inhibits SARS-CoV-2 Omicron and variant pseudovirus infection via ACE2-targeted mechanisms. FRONTIERS IN PHARMACOLOGY. 16. 2026
- Identification of Potential Multitarget Directed Ligands for Alzheimer's Disease by Coupling Virtual Screening and Experimental Validation. JOURNAL OF CHEMICAL INFORMATION AND MODELING. 66(5):2900-2917. 2026
- Molecular Mechanism of Beta-Amyloid Aggregation Inhibition by KLVFF. JOURNAL OF CHEMICAL INFORMATION AND MODELING. 66(1):684-700. 2026
- Differential Effects of Marimastat and Prinomastat on the Metalloprotease Activity of Various Snake Venoms. TOXINS. 17(12). 2025
- Discovery of a brain penetrant SGK1 inhibitor using a ligand- and structure-based virtual screening methodology. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY. 40(1). 2025
- Identification of druggable binding sites and small molecules as modulators of TMC1. COMMUNICATIONS BIOLOGY. 8(1). 2025
- MicroRNA signature of lymphoblasts from amyotrophic lateral sclerosis patients as potential clinical biomarkers. NEUROBIOLOGY OF DISEASE. 208. 2025
- Novel neuroglobin boosters as a therapeutic strategy for traumatic brain injury. INTERNATIONAL IMMUNOPHARMACOLOGY. 159. 2025
- The ROCK Inhibitor Fasudil and Sertraline Share Morphological and Molecular Effects in the Hippocampus of Chronically Stressed Rats: Exploring Common Antidepressant Pathways by Network Pharmacology. ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE. 8(5):1292-1312. 2025
- AlzyFinder: A Machine-Learning-Driven Platform for Ligand-Based Virtual Screening and Network Pharmacology. JOURNAL OF CHEMICAL INFORMATION AND MODELING. 64(24):9040-9047. 2024
- Antibacterial and Antiviral Properties of Chenopodin-Derived Synthetic Peptides. ANTIBIOTICS-BASEL. 13(1). 2024
- Constitutive sodium permeability in a C. elegans two-pore domain potassium channel. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 121(43). 2024
- Druggable cavities and allosteric modulators of the cell division cycle 7 (CDC7) kinase. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY. 39(1). 2024
- Enzymatic Metabolic Switches of Astrocyte Response to Lipotoxicity as Potential Therapeutic Targets for Nervous System Diseases. PHARMACEUTICALS. 17(5). 2024
- Identification of Antioxidant Methyl Derivatives of Ortho-Carbonyl Hydroquinones That Reduce Caco-2 Cell Energetic Metabolism and Alpha-Glucosidase Activity. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 25(15). 2024
- Impedimetric Sensor for SARS-CoV-2 Spike Protein Detection: Performance Assessment with an ACE2 Peptide-Mimic/Graphite Interface. BIOSENSORS. 14(12). 2024
- Intragastric administration of short chain fatty acids greatly reduces voluntary ethanol intake in rats. SCIENTIFIC REPORTS. 14(1). 2024
- Phase IIa randomized placebocontrolled clinical trial to evaluate the efficacy of bromhexine in combination with standard therapy in the early treatment of COVID-19 in primary care patients. REVISTA MEDICA DE CHILE. 152(12):1198-1208. 2024
- Repurposing the Open Global Health Library for the discovery of novel Mpro destabilizers with scope as broad-spectrum antivirals. FRONTIERS IN PHARMACOLOGY. 15. 2024
- Anti-Inflammatory Effect of Izalpinin Derived from Chromolaena leivensis: ¿-Carrageenan-Induced Paw Edema and In Silico Model. MOLECULES. 28(9). 2023
- Design of ß-Keto Esters with Antibacterial Activity: Synthesis, In Vitro Evaluation, and Theoretical Assessment of Their Reactivity and Quorum-Sensing Inhibition Capacity. PHARMACEUTICALS. 16(10). 2023
- Iridoid esters from Valeriana pavonii Poepp. & Endl. as GABAA modulators: Structural insights in their binding mode and structure-activity relationship. JOURNAL OF PHARMACY & PHARMACOGNOSY RESEARCH. 11(3):367-380. 2023
- Network pharmacology and topological analysis on tibolone metabolites and their molecular mechanisms in traumatic brain injury. BIOMEDICINE & PHARMACOTHERAPY. 165. 2023
- Trends and challenges in chemoinformatics research in Latin America. ARTIFICIAL INTELLIGENCE IN THE LIFE SCIENCES. 3. 2023
- Common Structural Pattern for Flecainide Binding in Atrial-Selective Kv1.5 and Nav1.5 Channels: A Computational Approach. PHARMACEUTICS. 14(7). 2022
- Crystal structure, Hirshfeld surface analysis, and molecular dynamics simulations of two isostructural N-propargyl-4-(2-oxopyrrolidin-1-yl)-1,2,3,4-tetrahydroquinolines. JOURNAL OF MOLECULAR STRUCTURE. 1254. 2022
- Identification of HMGCR, PPGARG and prohibitin as potential druggable targets of dihydrotestosterone for treatment against traumatic brain injury using system pharmacology. INTERNATIONAL IMMUNOPHARMACOLOGY. 108. 2022
- Network pharmacology reveals multitarget mechanism of action of drugs to be repurposed for COVID-19. FRONTIERS IN PHARMACOLOGY. 13. 2022
- Selective TASK-1 Inhibitor with a Defined Structure-Activity Relationship Reduces Cancer Cell Proliferation and Viability. JOURNAL OF MEDICINAL CHEMISTRY. 65(22):15014-15027. 2022
- Structural Insights into the Substrate Transport Mechanisms in GTR Transporters through Ensemble Docking. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 23(3). 2022
- TDP-43 Modulation by Tau-Tubulin Kinase 1 Inhibitors: A New Avenue for Future Amyotrophic Lateral Sclerosis Therapy. JOURNAL OF MEDICINAL CHEMISTRY. 65(2):1585-1607. 2022
- Tibolone Pre-Treatment Ameliorates the Dysregulation of Protein Translation and Transport Generated by Palmitic Acid-Induced Lipotoxicity in Human Astrocytes: A Label-Free MS-Based Proteomics and Network Analysis. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 23(12). 2022
- 5-(Indol-2-yl)pyrazolo[3,4-b]pyridines as a New Family of TASK-3 Channel Blockers: A Pharmacophore-Based Regioselective Synthesis. MOLECULES. 26(13). 2021
- Antimicrobial properties of novel ionic liquids derived from imidazolium cation with phenolic functional groups. BIOORGANIC CHEMISTRY. 115. 2021
- Application of ensemble pharmacophore-based virtual screening to the discovery of novel antimitotic tubulin inhibitors. COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL. 19:4360-4372. 2021
- From Kinase Inhibitors to Multitarget Ligands as Powerful Drug Leads for Alzheimer's Disease using Protein-Templated Synthesis. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 60(35):19344-19354. 2021
- Host-Directed FDA-Approved Drugs with Antiviral Activity against SARS-CoV-2 Identified by Hierarchical In Silico/In Vitro Screening Methods. PHARMACEUTICALS. 14(4). 2021
- Identification of a critical binding site for local anaesthetics in the side pockets of K(v)1 channels. BRITISH JOURNAL OF PHARMACOLOGY. 178(15):3034-3048. 2021
- PSC-db: A Structured and Searchable 3D-Database for Plant Secondary Compounds. MOLECULES. 26(4). 2021
- Screening for Interacting Proteins with Peptide Biomarker of Blood-Brain Barrier Alteration under Inflammatory Conditions. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 22(9). 2021
- Targeting nuclear protein TDP-43 by cell division cycle kinase 7 inhibitors: A new therapeutic approach for amyotrophic lateral. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. 210. 2021
- Analysis of theZonula occludensToxin Found in the Genome of the Chilean Non-toxigenicVibrio parahaemolyticusStrain PMC53.7. FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY. 10. 2020
- COVID-19: Drug Targets and Potential Treatments. JOURNAL OF MEDICINAL CHEMISTRY. 63(21):12359-12386. 2020
- Elucidating the Structural Basis of the Intracellular pH Sensing Mechanism of TASK-2 K2P Channels. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 21(2). 2020
- Identification of Mycobacterium tuberculosis CtpF as a target for designing new antituberculous compounds. BIOORGANIC & MEDICINAL CHEMISTRY. 28(3). 2020
- Structural and functional computational analysis of nicotine analogs as potential neuroprotective compounds in Parkinson disease. COMPUTATIONAL BIOLOGY AND CHEMISTRY. 86. 2020
- Discovery of Novel TASK-3 Channel Blockers Using a Pharmacophore-Based Virtual Screening. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 20(16). 2019
- Structure/Activity Analysis of TASK-3 Channel Antagonists Based on a 5,6,7,8 tetrahydropyrido[4,3-d]pyrimidine. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 20(9). 2019
- TASK Channels Pharmacology: New Challenges in Drug Design. JOURNAL OF MEDICINAL CHEMISTRY. 62(22):10044-10058. 2019
- The interplay of the metallosensor CueR with two distinct CopZ chaperones defines copper homeostasis in Pseudomonas aeruginosa. JOURNAL OF BIOLOGICAL CHEMISTRY. 294(13):4934-4945. 2019
- The molecular basis for an allosteric inhibition of K+-flux gating in K-2P channels. ELIFE. 8. 2019
- An important role for periplasmic storage in Pseudomonas aeruginosa copper homeostasis revealed by a combined experimental and computational modeling study. MOLECULAR MICROBIOLOGY. 110(3):357-369. 2018
- Is It Reliable to Take the Molecular Docking Top Scoring Position as the Best Solution without Considering Available Structural Data?. MOLECULES. 23(5). 2018
- Novel Alkylimidazolium Ionic Liquids as an Antibacterial Alternative to Pathogens of the Skin and Soft Tissue Infections. MOLECULES. 23(9). 2018
- Exploring and understanding the functional role, and biochemical and structural characteristics of an acidic phospholipase A(2), ApITx-I, purified from Agkistrodon piscivorus leucostoma snake venom. TOXICON. 127:22-36. 2017
- Origin and evolution of transporter substrate specificity within the NPF family. ELIFE. 6. 2017
- Side Fenestrations Provide an "Anchor" for a Stable Binding of A1899 to the Pore of TASK-1 Potassium Channels. MOLECULAR PHARMACEUTICS. 14(7):2197-2208. 2017
- CoaTx-II, a new dimeric Lys49 phospholipase A(2) from Crotalus oreganus abyssus snake venom with bactericidal potential: Insights into its structure and biological roles. TOXICON. 120:147-158. 2016
- Computational methods applied to rational drug design. OPEN MEDICINAL CHEMISTRY JOURNAL. 10:7-20. 2016
- Functional mutagenesis screens reveal the 'cap structure' formation in disulfide-bridge free TASK channels. SCIENTIFIC REPORTS. 6. 2016
- Is It Reliable to Use Common Molecular Docking Methods for Comparing the Binding Affinities of Enantiomer Pairs for Their Protein Target?. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 17(4). 2016
- Novel N-allyl/propargyl tetrahydroquinolines: Synthesis via Three-component Cationic Imino Diels-Alder Reaction, Binding Prediction, and Evaluation as Cholinesterase Inhibitors. CHEMICAL BIOLOGY & DRUG DESIGN. 88(4):498-510. 2016
- Kv1.5 blockers preferentially inhibit TASK-1 channels: TASK-1 as a target against atrial fibrillation and obstructive sleep apnea?. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY. 467(5):1081-1090. 2015
- Computational insights of the interaction among sea anemones neurotoxins and Kv1.3 channel. BIOINFORMATICS AND BIOLOGY INSIGHTS. 8:73-81. 2014
- Theoretical and Experimental Exploration of Organic Synthesis Routes to Obtain Natural Rubber Analogues. JOURNAL OF MATERIALS SCIENCE AND ENGINEERING A. 4(9):290-296. 2014
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libro
Contacto
nombre completo
- David Mauricio Ramirez Sanchez
correos electrónicos adicionales
- dramirezs@udec.cl
red de Coautor
Mapa de la ciencia