artículo académico

• Molecular Mechanism of Beta-Amyloid Aggregation Inhibition by KLVFF.  JOURNAL OF CHEMICAL INFORMATION AND MODELING.  66(1):684-700. 2026
• Unraveling the neuroprotective mechanisms of elephant black garlic extract against beta amyloid peptide-induced neurotoxicity.  FRONTIERS IN NUTRITION.  12. 2026
• Allosteric modulation and direct activation of glycine receptors by a tricyclic sulfonamide..  SCIENTIFIC REPORTS.  15(1). 2025
• Deciphering the Neurotoxic Effects of Karenia selliformis.  TOXINS.  17(2). 2025
• In Silico Characterization of Gelsemium Compounds as Glycine Receptor Ligands.  COMPOUNDS.  5(4). 2025
• Neuroprotective Activity of 3-((6-(Phenylethynyl)pyridin-3- yl)oxy)quinuclidine: A Potential Ligand for the Treatment of Alzheimer's Disease.  ACS CHEMICAL NEUROSCIENCE.  16(23):4502-4510. 2025
• Potential Antioxidant and Neuroprotective Effect of Polysaccharide Isolated from Digüeñe Cyttaria espinosae.  JOURNAL OF FUNGI.  11(9). 2025
• The Alkaloid Gelsemine Reduces Aß Peptide Toxicity by Targeting Transglutaminase Type 2 Enzyme.  PLANTS-BASEL.  14(10). 2025
• Evaluation of the bioactivity of Berberis microphylla G. Forst (Calafate) leaves infusion.  FOOD BIOSCIENCE.  62. 2024
• Molecular Pharmacology of Gelsemium Alkaloids on Inhibitory Receptors.  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES.  25(6). 2024
• Phase IIa randomized placebocontrolled clinical trial to evaluate the efficacy of bromhexine in combination with standard therapy in the early treatment of COVID-19 in primary care patients.  REVISTA MEDICA DE CHILE.  152(12):1198-1208. 2024
• Modulation of GABAA receptors and of GABAergic synapses by the natural alkaloid gelsemine.  FRONTIERS IN MOLECULAR NEUROSCIENCE.  15. 2023
• Neuroprotective Properties of Eudesmin on a Cellular Model of Amyloid-beta Peptide Toxicity.  JOURNAL OF ALZHEIMERS DISEASE.  94:S97-S108. 2023
• New Benzodihydrofuran Derivatives Alter the Amyloid beta Peptide Aggregation: Strategies To Develop New Anti-Alzheimer Drugs.  ACS CHEMICAL NEUROSCIENCE.  14(15):2590-2602. 2023
• Partial Inhibition of Complex I Restores Mitochondrial Morphology and Mitochondria-ER Communication in Hippocampus of APP/PS1 Mice.  CELLS.  12(8). 2023
• TG2 promotes amyloid beta aggregates: Impact on ER-mitochondria crosstalk, calcium homeostasis and synaptic function in Alzheimer's disease.  BIOMEDICINE & PHARMACOTHERAPY.  162. 2023
• Understanding the Role of ATP Release through Connexins Hemichannels during Neurulation.  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES.  24(3). 2023
• Antiseizure medication in early nervous system development. Ion channels and synaptic proteins as principal targets.  FRONTIERS IN PHARMACOLOGY.  13. 2022
• Metabolic profile and antioxidant capacity of five Berberis leaves species: A comprehensive study to determine their potential as natural food or ingredient.  FOOD RESEARCH INTERNATIONAL.  160. 2022
• Increased P2x2 receptors induced by amyloid-beta peptide participates in the neurotoxicity in alzheimer's disease.  BIOMEDICINE & PHARMACOTHERAPY.  142. 2021
• Phenolic Compounds in Calafate Berries Encapsulated by Spray Drying: Neuroprotection Potential into the Ingredient.  ANTIOXIDANTS.  10(11). 2021
• The Administration of the Synbiotic Lactobacillus bulgaricus 6c3 Strain, Inulin and Fructooligosaccharide Decreases the Concentrations of Indoxyl Sulfate and Kidney Damage in a Rat Model.  TOXINS.  13(3). 2021
• Altered Glutaminase 1 Activity During Neurulation and Its Potential Implications in Neural Tube Defects.  FRONTIERS IN PHARMACOLOGY.  11. 2020
• Changes in PGC-1 alpha/SIRT1 Signaling Impact on Mitochondrial Homeostasis in Amyloid-Beta Peptide Toxicity Model.  FRONTIERS IN PHARMACOLOGY.  11. 2020
• Inhibition of the Glycine Receptor alpha 3 Function by Colchicine.  FRONTIERS IN PHARMACOLOGY.  11. 2020
• Modulation of glycine receptor single-channel conductance by intracellular phosphorylation.  SCIENTIFIC REPORTS.  10(1). 2020
• Stereospecific Inhibition of Ethanol Potentiation on Glycine Receptor by M554 Stereoisomers.  JOURNAL OF CHEMICAL INFORMATION AND MODELING.  60(12):6634-6641. 2020
• 17 Oxo Sparteine and Lupanine, Obtained from Cytisus scoparius, Exert a Neuroprotection against Soluble Oligomers of Amyloid-beta Toxicity by Nicotinic Acetylcholine Receptors.  JOURNAL OF ALZHEIMERS DISEASE.  67(1):343-356. 2019
• Exploring the Role of P2X Receptors in Alzheimer's Disease.  FRONTIERS IN PHARMACOLOGY.  10:1330-1339. 2019
• Exposure to UV-B Radiation Leads to Increased Deposition of Cell Wall-Associated Xerocomic Acid in Cultures of Serpula himantioides.  APPLIED AND ENVIRONMENTAL MICROBIOLOGY.  85(18):1-13. 2019
• Inhibitory Actions of Tropeines on the alpha 3 Glycine Receptor Function.  FRONTIERS IN PHARMACOLOGY.  10. 2019
• Large Intracellular Domain-Dependent Effects of Positive Allosteric Modulators on Glycine Receptors.  ACS CHEMICAL NEUROSCIENCE.  10(5):2551-2559. 2019
• Neuroprotective effects of EpoL against oxidative stress induced by soluble oligomers of A beta peptide.  REDOX BIOLOGY.  24:1-12. 2019
• A Natural Benzofuran from the Patagonic Aleurodiscus vitellinus Fungus has Potent Neuroprotective Properties on a Cellular Model of Amyloid-beta Peptide Toxicity.  JOURNAL OF ALZHEIMERS DISEASE.  61(4):1463-1475. 2018
• Cytotoxicity and in vivo plasma kinetic behavior of surface-functionalized PAMAM dendrimers.  NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE.  14(7):2227-2234. 2018
• Neuroprotective effect of a new variant of Epo nonhematopoietic against oxidative stress.  REDOX BIOLOGY.  14:285-294. 2018
• P2X receptor overexpression induced by soluble oligomers of amyloid beta peptide potentiates synaptic failure and neuronal dyshomeostasis in cellular models of alzheimer´s disease.  NEUROPHARMACOLOGY.  128:366-378. 2018
• Prevention of Synaptic Alterations and Neurotoxic Effects of PAMAM Dendrimers by Surface Functionalization.  NANOMATERIALS.  8(1):1-12. 2018
• ATP leakage induces P2XR activation and contributes to acute synaptic excitotoxiciw induced by soluble oligomers of beta-amyloid peptide in hippocampal neurons.  NEUROPHARMACOLOGY.  100:116-123. 2016
• Bioequivalence Study of Two Hydrochlorothiazide Formulations after Oral Administration in Healthy Chilean Volunteers.  JOURNAL OF PHARMACY AND PHARMACOLOGY (DAVID PUBLISHING).  4(12):679-685. 2016
• Functional modulation of glycine receptors by the alkaloid gelsemine.  BRITISH JOURNAL OF PHARMACOLOGY.  173(14):2263-2277. 2016
• Impact of mitichondrial dysfunction on neurodegenerative diseases: A key step on Alzheimer´s disease.  JOURNAL OF SYSTEMS AND INTEGRATIVE NEUROSCIENCE.  2(3):169-176. 2016
• Reversal of Ethanol-Induced Intoxication by a Novel Modulator of Gß¿ Potentiation of Glycine Receptor.  JOURNAL OF BIOLOGICAL CHEMISTRY.  291:18791-18798. 2016
• Modulation of the neuronal network activity by P2X receptors and their involvement in neurological disorders.  PHARMACOLOGICAL RESEARCH.  109-115. 2015
• Neurotoxin-like compounds from the ichthyotoxic red tide alga Heterosigma akashiwo induce a TTX-like synaptic silencing in mammalian neurons.  HARMFUL ALGAE.  47:1-8. 2015
• Copper-uptake is critical for the down regulation of synapsin and dynamin induced by neocuproine: modulation of synaptic activity in hippocampal neurons.  FRONTIERS IN AGING NEUROSCIENCE.  6(319):1-10. 2014
• Modulation of Neuronal Nicotinic Receptor by Quinolizidine Alkaloids Causes Neuroprotection on a Cellular Alzheimer Model.  JOURNAL OF ALZHEIMERS DISEASE.  42(1):143-155. 2014
• Inhibition of the Ethanol-induced Potentiation of a1 Glycine Receptor by a Small Peptide That Interferes with Gby Binding.  JOURNAL OF BIOLOGICAL CHEMISTRY.  287(48):40713-40721. 2012
• Synaptic Silencing and Plasma Membrane Dyshomeostasis induced by Amyloid-b peptide are Prevented by Aristotelia chilensis Enriched Extract.  JOURNAL OF ALZHEIMERS DISEASE.  31:879-889. 2012
• Cloning and Spatiotemporal Expression of RIC-8 in Xenopus embryogenesis.  GENE EXPRESSION PATTERNS.  11:401-408. 2011
• Inhibitory activities on Mammalian Central Nervous System Receptors and Computational Studies of Three Sesquiterpene lactones from Coraria ruscifolia subsp. Ruscifolia.  CHEMICAL & PHARMACEUTICAL BULLETIN.  59(2):161-165. 2011
• Synaptic failure and adenosine triphosphate imbalance induced by amyloid-B aggregates are prevented by blueberry-enriched polyphenol extract.  JOURNAL OF NEUROSCIENCE RESEARCH.  89:1499-1508. 2011
• Impact of balance training with a virtual reality in elderly.  INTERNATIONAL JOURNAL OF MORPHOLOGY.  28(1):303-308. 2010
• Impacto del Entrenamiento del Balance a Través de Realidad Virtual en una Población de Adultos Mayores.  INTERNATIONAL JOURNAL OF MORPHOLOGY.  28(1):303-308. 2010
• Potentiation and Inhibition of Glycine Receptors by Tutin.  NEUROPHARMACOLOGY.  2010
• Blockade of Ethanol-Induced Potentiation of Glycine Receptors by a Peptide that Interferes with Gbetasigma Binding.  JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS.  331(3):933-939. 2009
• Inhibitory Effects of Tutin on Glycine Receptors in Spinal Neurons.  EUROPEAN JOURNAL OF PHARMACOLOGY.  559:61-64. 2007
• Tight Coupling of the t-SNARE and Calcium Channel Microdomains in Adrenomedullary Slices and not in Cultured Chramaffin Cells.  CELL CALCIUM.  41:547-558. 2007
• Historical and Current Perspectives of Neuroactive Compounds Derived from Latin America.  JOURNAL OF MEDICINAL CHEMISTRY.  6:997-1008. 2006